Kevin Bi (bioinformatics engineer) studied Biochemistry at Columbia University, where he worked in Christian Schindler's laboratory on the transcriptional profiling of lung macrophages. In the Haining Lab, Kevin uses single cell transcriptional profiling approaches to characterize lymphocyte differentiation in cancer and viral infection models. He spends his free time reading, writing, and trying to find a piano.
Flavian Brown (graduate student) is a 2009 alumnus of Carleton College, where he earned a B.A. in Biology. As an undergraduate, he studied non-small cell lung cancer in Stuart Schreiber's laboratory at the Broad Institute. His graduate work focuses on understanding how lymph node stromal cells regulate T cell biology. A recent newlywed, Flavian loves traveling to new places with his wife Austyn. He also enjoys volunteer opportunities, mentoring and shopping.
Collins Cheruiyot (lab technician) worked on exosomes and HIV/host protein interactions while studying for his B.Sc. in Applied Mathematics and Biology at Brown University. Since joining the Haining Lab, Collins works with Rob, Hans, and Margaret to study tumor resistance to immunotherapy. Outside his research, Collins enjoys swimming, reading and a cup of hot chocolate.
Natalie Collins (clinical fellow) completed her MD/PhD training at the University of Virginia in the lab of Gary Kupfer, studying molecular pathogenesis of Fanconi anemia. She is now a fellow in Pediatric Hematology/Oncology, and is interested in tumor immunology and why some tumors are susceptible to immune responses and others are not. When she isn't working she's playing with her daughter Laurel and son Evan, enjoying Boston, or playing the trombone.
Dawn Comstock (graduate student) graduated from Gustavus Adolphus College, where her research focused on characterizing genes important for biofilm formation in M. xanthus and identifying rare genetic variants in familial cancers. In addition, she studied systems biology and gene regulation in immune cells in Ronald Germain's laboratory at the NIH. She is focusing her graduate studies on why some tumors are resistant to immunotherapy. Outside the lab she enjoys sports, traveling, and knitting.
Peter Du (research associate) studied the cytoplasmic domain of MHCI with regards to NMDAR regulation under the guidance of Lisa Boulanger at Princeton University. In the Haining lab, he's researching the immune resistance mechanisms of tumors in mice. In his free time, Peter likes to go swimming, watch anime, or curl up with a good book.
Juan Dubrot (research scientist) received his PhD in Spain for his work on cancer immunology and immunotherapy, then moved to Switzerland to expand his studies of the tumor microenvironment and the role of stromal cells in autoimmunity and cancer. In the Haining lab, Juan is part of the TIDE project, which aims to discover novel immunotherapy targets and mechanisms of tumor resistance. When he's not in the lab, Juan spends most of his time with his wife Carmen, exploring their new home or trying to get Celtics tickets.
Jeff Ishizuka (post-doc) earned his D.Phil. in immunology studying CD8+ T-cell immunodominance and cross-reactivity with Sir Andrew McMichael at Oxford and Jon Yewdell at the NIH. He completed medical school at Harvard, internal medicine residency at Brigham and Women’s Hospital, and is now a medical oncology fellow. In the lab, he studies how tumors shape the immune microenvironment. Outside the lab, he and his wife, Jules, pine for the day when they can get a dog.
Marty LaFleur (graduate student) previously worked on a nanoparticle-based drug delivery platform for combatting drug resistance in the laboratories of Richard Partch and Craig Woodworth at Clarkson University. In the Haining lab, Marty is using CRISPR-Cas9 to engineer immune cell populations to combat tumors. When he's not in the lab, Marty spends his time watching the Patriots, trying new restaurants, and telling the funniest puns you've never heard.
Sarah Kate Lane-Reticker (research associate) studied Biochemistry at Colby College and worked in Derry Roopenian’s lab at the Jackson Laboratory, researching the development of T follicular helper cells and their role in autoimmunity. When not investigating tumor responses to immunotherapy with Team TIDE, she may be found on some kind of boat, hiking a mountain, baking, or reading.
Rob Manguso (graduate student) studied mechanisms of ciliogenesis in sea urchins at Wheaton College (MA) and as a Fulbright scholar in Lotte Pedersen’s lab at the University of Copenhagen. In the Haining Lab, Rob is studying the mechanisms used by tumor cells to evade detection by the immune system and lymphocyte responses to inhibition in the tumor microenvironment. When not in the lab, Rob spends his time hiking the 4,000 foot peaks of New England with his labradoodle, Murphy.
Brian Miller (post-doc) earned his MD/PhD at Washington University in St. Louis working in the lab of Dr. Skip Virgin studying autophagy in lymphocytes and osteoclasts. He is now interested in the tumor microenvironment and the immune response to cancer. Outside the lab and clinic, he enjoys spending his time with his wife Yamini (who is too good for him), fancy meals, and long distance running and biking.
Martha Neagu (post-doc) completed her MD/PhD training at Columbia University and in Switzerland in the lab of Jeremy Luban curing HIV in mice. She then completed a neurology residency at Harvard and is now a fellow in Neuro-Oncology interested in immune-evasion mechanisms of brain tumors. In her free time, she is all about music (playing piano and chamber music, listening, singing in the shower, and helping injured musicians heal) and art, and is growing one lovely tomato on her porch.
Hans Pope (lab technician) studied the sensory roles of cilia during heart muscle regeneration in zebrafish under the guidance of Robert Morris at Wheaton College. Working closely with Rob in the Haining Lab, he studies immune resistance mechanisms in mouse tumors. When he’s not in the lab, you can almost certainly find Hans rock climbing, listening to EDM, or both.
Debattama "Deb" Sen (graduate student) worked on improving laparoscopic surgeries while studying Biomedical Engineering and Computer Science at Columbia University. She also examined the pathogenic role of complement proteins in Huntington's Disease in Beth Steven's lab at Harvard Medical School. Currently, Deb is working to define the epigenetic landscape of exhausted T cells chronic viral infections. In her spare time, she likes to binge-watch Netflix shows or curl up with a good book.
Hsiao-Wei Tsao (post-doctoral fellow) received his PhD from the National Taiwan University, where he studied the transcriptional regulation of cytokine genes in Th1 cells in Shi-Chuen Miaw's lab. Since joining the Haining Lab, Hsiao-Wei has been working with Mike and Tony to elucidate the transcriptional networks governing CD8+ T cell differentiation.
Kathleen Yates (staff scientist) studied microbiology and immunology at McGill University in Montreal, Canada, where she researched the interactions of innate cellular pathways with HIV. In addition to managing the Haining lab, she studies mechanisms of T cell dysfunction in chronic viral infections. She's been working with Nick since he started his own lab and still can't believe how much caffeine he drinks.
Margaret Zimmer (lab technician) studied the mechanisms of actin cytoskeleton regulation under the guidance of Kenneth Campellone at the University of Connecticut, where she also played Division I Women's Ice Hockey. Since joining the Haining lab, she works closely with Rob and Hans studying tumor resistance to immunotherapies. Outside the lab, you can find Margaret on the ice playing for the Boston Blades or binge-watching the next big thing on Netflix.
Nick Haining (principal investigator) trained as a pediatric oncologist at the Dana Farber Cancer Institute and Children's Hospital Boston before doing a post-doc in Lee Nadler's laboratory at Dana Farber Cancer Institute. He started his own lab at DFCI in 2008, and still sees patients in the Jimmy Fund Clinic and at Children's Hospital. He also does weddings and bar mitzvahs.